Rheumatology-Rhumatologie
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Arthritis Research & Therapy | Abstract | The preclinical pharmacology of the high affinity anti-IL-6R Nanobody® ALX-0061 supports its clinical development in rheumatoid arthritis

The pleiotropic cytokine interleukin-6 (IL-6) plays an important role in the pathogenesis of different diseases, including rheumatoid arthritis (RA).

Via Krishan Maggon
Krishan Maggon 's curator insight, May 21, 2015 1:52 PM
The preclinical pharmacology of the high affinity anti-IL-6R Nanobody® ALX-0061 supports its clinical development in rheumatoid arthritis

Maarten Van Roy1*, Cedric Ververken1, Els Beirnaert12, Sven Hoefman1, Joost Kolkman13, Michel Vierboom4, Elia Breedveld4, Bert ‘t Hart45, Sofie Poelmans1, Lieselot Bontinck1, Alex Hemeryck1, Sandy Jacobs1, Judith Baumeister1and Hans Ulrichts1

*Corresponding author: Maarten Van Roy maarten.vanroy@ablynx.com

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Arthritis Research & Therapy 2015, 17:135  doi:10.1186/s13075-015-0651-0

Published: 20 May 2015
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IL-6 inhibitors for treatment of rheumatoid arthritis: past, present, and future - Online First - Springer

IL-6 inhibitors for treatment of rheumatoid arthritis: past, present, and future - Online First - Springer | Rheumatology-Rhumatologie | Scoop.it
 In this article, we review the mechanism of anti-IL-6 in the treatment of RA, provide the key efficacy
and safety data from clinical trials of approved anti-IL-6, TCZ, as well as six candidate IL-6 blockers
including sarilumab, ALX- 0061, sirukumab, MEDI5117, clazakizumab, and olo ...Cited by 1 Cite Save

Via Krishan Maggon
Krishan Maggon 's curator insight, April 29, 2015 5:08 AM
IL-6 inhibitors for treatment of rheumatoid arthritis: past, present, and futureGW Kim, NR Lee, RH Pi, YS Lim, YM Lee… - Archives of pharmacal …, 2015 - Springer...