Sphingolipids are important in many brain functions but their role in Alzheimer’s disease (AD) is not completely defined. A major limit is availability of fresh brain tissue with defined AD pathology.
Via Krishan Maggon
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Krishan Maggon 's curator insight,
March 3, 2015 11:55 AM
Beta amyloid was detected in younger brains 20 yr of age.
Brain Neuronal amyloid-β accumulation within cholinergic basal forebrain in ageing and Alzheimer’s disease Alaina Baker-Nigh , Shahrooz Vahedi , Elena Goetz Davis , Sandra Weintraub , Eileen H. Bigio , William L. Klein , Changiz GeulaDOI: http://dx.doi.org/10.1093/brain/awv024 First published online: 2 March 2015
Krishan Maggon 's curator insight,
February 19, 2015 3:26 AM
Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer’s diseaseElizabeta Gjoneska,Andreas R. Pfenning,Hansruedi Mathys,Gerald Quon,Anshul Kundaje,Li-Huei Tsai& Manolis KellisAffiliationsContributionsCorresponding authorsNature 518, 365–369 (19 February 2015) doi:10.1038/nature14252Received 07 January 2014 Accepted 22 January 2015 Published online 18 February 2015
Krishan Maggon 's curator insight,
January 11, 2015 4:29 AM
Pharmacological Reports
Volume 67, Issue 2, April 2015, Pages 195–203 Review article A review on Alzheimer's disease pathophysiology and its management: an updateAnil Kumar, , , Arti Singh, Ekavali doi:10.1016/j.pharep.2014.09.004
Krishan Maggon 's curator insight,
November 2, 2014 1:56 AM
Review Immunotherapy for Alzheimer’s disease: hoops and hurdlesCynthia A Lemere Correspondence: Cynthia A Lemere clemere@partners.org Author Affiliations Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, NRB 636F, 77 Avenue Louis Pasteur, Boston 02115, MA, USA Molecular Neurodegeneration 2013, 8:36 doi:10.1186/1750-1326-8-36 The electronic version of this article is the complete one and can be found online at:http://www.molecularneurodegeneration.com/content/8/1/36 Received:3 July 2013Accepted:23 September 2013Published:22 October 2013 © 2013 Lemere; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Krishan Maggon 's curator insight,
September 20, 2014 4:47 PM
open access Crystal structure reveals conservation of amyloid-β conformation recognized by 3D6 following humanization to bapineuzumab Hadar Feinberg2, José W Saldanha5, Linnea Diep1, Amita Goel1, Angela Widom3,Geertruida M Veldman6, William I Weis2, Dale Schenk4 and Guriqbal S Basi1* *Corresponding author: Guriqbal S Basi gur1balbasi@gmail.com Author Affiliations 1Elan Pharmaceuticals, Inc. 300 Technology Sq., Cambridge, MA 02139, USA 2Departments of Structural Biology and of Molecular & Cellular Physiology, 299 Campus Drive, Stanford University School of Medicine, Stanford, CA 94305, USA 3Pfizer, Cambridge, MA, USA 4Prothena Biosciences, Inc., 650 Gateway Blvd., San Francisco, CA 94080, USA 5National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK 6Abbvie Bioresearch Center, Worcester, MA, USA For all author emails, please log on. Alzheimer's Research & Therapy 2014, 6:31 doi:10.1186/alzrt261 |
Krishan Maggon 's curator insight,
March 18, 2015 4:11 AM
Citation: Aubry S, Shin W, Crary JF, Lefort R, Qureshi YH, et al. (2015) Assembly and Interrogation of Alzheimer’s Disease Genetic Networks Reveal Novel Regulators of Progression. PLoS ONE 10(3): e0120352. doi:10.1371/journal.pone.0120352
Krishan Maggon 's curator insight,
March 2, 2015 2:10 AM
NATURE IMMUNOLOGY | REVIEW Innate immunity in Alzheimer's diseaseMichael T Heneka,Douglas T Golenbock& Eicke LatzAffiliationsCorresponding authorNature Immunology 16, 229–236 (2015) doi:10.1038/ni.3102Received 03 December 2014 Accepted 13 January 2015 Published online 17 February 2015
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January 11, 2015 4:37 AM
Neurobiology of Disease Volume 73, January 2015, Pages 137–149 Review Eph receptors: New players in Alzheimer's disease pathogenesisMoustapha Cissé, , Frédéric Checler, doi:10.1016/j.nbd.2014.08.028
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November 16, 2014 3:21 AM
Amyloid Beta Precursor Protein: Proper Credit for the Basic Biochemical Properties of the Most Studied Protein in the 21st Century*Franco R , Navarro G, Martínez-Pinilla E and Moreno E JOURNAL OF NEUROLOGY AND NEUROLOGICAL DISORDERS
Copyright: © 2014 Franco R. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Krishan Maggon 's curator insight,
October 20, 2014 12:43 PM
A small molecule binding HMGB1 and HMGB2inhibits microglia-mediated neuroinflammationSanghee Lee,Youngpyo Nam,Ja Young Koo,Donghyun Lim,Jongmin Park,Jiyeon Ock,Jaehong Kim,Kyoungho Suk& Seung Bum ParkAffiliationsContributionsCorresponding authorsNature Chemical Biology (2014) doi:10.1038/nchembio.1669Received 19 March 2014 Accepted 18 September 2014 Published online 12 October 2014
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Citation: Fonteh AN, Ormseth C, Chiang J, Cipolla M, Arakaki X, et al. (2015) Sphingolipid Metabolism Correlates with Cerebrospinal Fluid Beta Amyloid Levels in Alzheimer’s Disease. PLoS ONE 10(5): e0125597. doi:10.1371/journal.pone.0125597